Embryo Screening

Day 3 embryo biopsy performed 3 days after fertilization, when the embryo is typically composed of six to eight cells. A hole is made in the outer shell of the embryo and one or two cells are removed for genetic analysis.

Josh Clark
Mary Jane
Nix Maxwell

Day 5/6 embryo biopsy (blastocyst biopsy) performed five or six days after fertilization. By this time, the embryo should have developed to the blastocyst stage, comprising an inner cell mass (which will go on to form the fetus) and trophectoderm cells (which will go on to form the placenta). Approximately five trophectoderm cells are removed for genetic analysis.

Josh Clark
Mary Jane
Nix Maxwell

Importantly, PGD is not able to correct a genetic abnormality, but only to identify embryos with a genetic abnormality and exclude them from transfer to establish a healthy pregnancy outcome.

In summary
The Preimplantation Genetics Diagnosis (PGD) helps couples with high risk of transmitting a genetic disease to their child.
Selection of healthy embryos free of concerned genetic disorder for the transferred in IVF process.
Can be performed for >99% of inherited single gene disorders.
Identifies affected and unaffected embryos with >98% of accuracy.
Women who become pregnant through PGD receive routine prenatal care.
Avoids the traumatic option for couple who have affected fetus either to have an affected child or decide on termination of pregnancy.
It allows parents to be to prevent an incurable genetic disease before implantation and prior to actual pregnancy which increases the
chances of baby being born free of that genetic disease.